What Are The Advantages Of Cryo-Correlative Light And Electron Microscopy?
Researchers in life sciences are using a combination of cryo-electron microscopy and light microscopy to gain new insights into their research. In this blog post, we discuss the reasons behind this dual technique’s use and its advantages. Correlative light and electron microscopy (CLEM) is a set of techniques that integrate information from images acquired through both […]
How Cryo-Electron Microscopy Can Accelerate Drug Discovery
Cryo-EM is a powerful tool in structural biology, allowing researchers to obtain high-resolution reconstructions of macromolecular structures. Here, we will discuss the role of cryo-EM in drug discovery and its potential to revolutionize the field. Drug discovery plays a crucial role in healthcare, but the process is very costly and time-consuming. Fortunately, advancements in molecular […]
Cryo-FIB Lift-Out: Enabling Cryo-ET Imaging for Tissues
As the boundaries of cryo-electron tomography are continuously being pushed, there are major advancements in the development of cryo-FIB lift-out techniques, which enable the imaging of tissue sections. What are the latest developments? Cryo-electron tomography (Cryo-ET) has transformed our understanding of the structural organization and functioning of proteins and macromolecules in their near-native state. In […]
What is the difference between cryo-EM and cryo-ET?
Advancements in technology increased the popularity of cryo-electron microscopy (cryo-EM) techniques such as cryo-electron tomography (cryo-ET) and single-particle analysis (SPA). For those new to the field, this blog post explains the difference between cryo-EM and cryo-ET. Cryo-electron microscopy (cryo-EM) is a general term for performing electron microscopy at cryogenic temperatures. When imaging with an electron microscope, […]
