DELMIC KOL INTERVIEW SERIES 01
Professor Yoshiyuki Kubota: Mapping the Microcircuitry of the Cortex For more than forty years, one question has shaped Professor Yoshiyuki Kubota’s research: how is the cortex actually wired? This is the story of that pursuit – and why array tomography became the tool that could finally begin to answer it. Ask Professor Yoshiyuki Kubota why […]
The evolution of fluorescence-guided lamella milling: From stand-alone to tri-coincident systems
Cryo-electron tomography (cryo-ET) offers unprecedented, high-resolution insights into the molecular ultrastructure of cells. However, locating specific targets and preparing the perfect electron-transparent lamella remains a significant bottleneck. Traditionally, researchers had to rely on a stand-alone fluorescence microscope (FM) to identify targets before physically transferring the delicate grid to the FIB-SEM. This transfer is inherently risky, […]
Beyond the research paper: 5 workflow secrets for cleaner lamellae and faster results
The “real” side of the lab While academic papers usually focus on the final results, METEOR Connect 2026 was designed to explore the “real” side of the lab. We organized this event because our commitment to customers spans from sale to result; we love seeing METEOR in active use and listening closely to our community. Instead of […]
5 Key Challenges in Cryo-FIB Targeting — and How to Overcome Them
Achieving high-accuracy targeting in cryo-focused ion beam (cryo-FIB) workflows is essential for generating high-quality lamellae for cryo-electron tomography (cryo-ET). But accuracy doesn’t come easy: successful targeting requires more than a high-resolution image. At every stage in the lamella creation workflow — from identifying the region of interest (ROI) to the final milling step — multiple […]
See More with Less: Discover the Power of METEOR 2.0
We’re excited to unveil METEOR 2.0, the next evolution of our integrated cryo-fluorescence microscope (cryo-FM) designed to simplify and accelerate your cryo-electron tomography (cryo-ET) workflow. Building on the proven foundation of METEOR 1.0, the new system offers faster targeting, greater sensitivity, and enhanced ease of use, allowing researchers to confidently identify and target regions of interest—without added contamination risk or […]
The case for sensitivity in integrated fluorescence microscopes
Introduction In the rapidly evolving field of cryo-electron tomography (cryo-ET), the ability to efficiently target and image regions of interest (ROIs) within lamellae is paramount. Delmic’s integrated fluorescence microscopes, METEOR and ENZEL, have emerged as game-changers, enhancing workflow efficiency and enabling researchers to achieve unprecedented sensitivity and precision in their studies. With over 25 customers […]
Exploring cryo-plasma FIB/SEM volume imaging for biological specimens
In the rapidly evolving field of biological imaging, a recent study has explored the untapped potential of serial cryogenic plasma-focused ion beam scanning electron microscopy (cryo-serial pFIB/SEM) to visualize biological samples with unprecedented clarity and detail. Cryo-serial plasma FIB/SEM represents a leap forward in biological imaging. It allows scientists to examine cells, tissues, and even […]
How to reduce contamination in Cryo-ET with advanced Cryo-FIB techniques
Cryogenic electron tomography (cryo-ET) is a powerful technique that enables researchers to visualize macromolecular complexes within their near-native cellular environment [1,2]. This method has revolutionized the field of structural biology by providing insights into the organization and function of cellular components at near-atomic resolution [3]. However, for cryo-ET to be effective, the sample must be […]
Addressing ice contamination challenges in the Cryo-ET workflow
Cryo-electron tomography (Cryo-ET) is a powerful imaging technique that enables the visualization of biomolecular structures in their near-native state at subnanometer resolutions. By combining a series of 2D images taken at different tilt angles into a 3D reconstruction, cryo-ET provides unparalleled insights into protein-protein interactions and molecular machinery within cells. This powerful technique has revolutionized […]
What Are The Advantages Of Cryo-Correlative Light And Electron Microscopy?
Researchers in life sciences are using a combination of cryo-electron microscopy and light microscopy to gain new insights into their research. In this blog post, we discuss the reasons behind this dual technique’s use and its advantages. Correlative light and electron microscopy (CLEM) is a set of techniques that integrate information from images acquired through both […]
