Understanding the wiring of the brain requires visualizing its constituent cells with electron microscopy, the only technique that can visualize the nanoscale details that define individual cells. By using high-throughput electron microscopy, these details can be collected on a large scale, providing data for a full map of all interactions in the brain, helping researchers examine processes like behaviour, memory, and decision making.
One of the most fascinating challenges in neuroscience is the mapping of the complete connectivity of the brain. Recent years have seen a rapid expansion in the field of connectomics, the study of tracing and understanding this connectivity map. One of the methods of choice in the field of connectomics is 3D electron microscopy (3D EM). 3D EM enables imaging of large volumes of brain tissue at nanoscale resolution, to study the structures that define individual brain cells and interactions with other cells, even at long distances.
Delmic’s Fast EM drastically accelerates the data collection steps required for connectomics, in a system that combines that combines high spatial resolution with high speed and automation. Fast EM speeds up existing projects and enables projects previously unfeasible with conventional scanning EMs.
Delmic’s Fast EM solution is highly suited for neuroscience thanks to its high sustained throughput. The high level of automation enables large-scale 3D EM workflows with minimal operator supervision. Volumes of interest are rapidly collected, which enables neuronal tracing over large distances and a better understanding of cellular interactions in the brain.
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Call +31 (0)15 744 01 58 or book a meeting on his agenda.
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