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METEOR 2.0

High-quality fluorescence imaging integrated into your cryo-FIB/SEM

Streamline your cryo-ET workflow with faster imaging, higher targeting accuracy, and a contamination-free process—delivering superior results for your research.

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Create more high-quality lamellae in less time

Reduce risky transfer steps in your cryo-ET workflow while improving ROI targeting for high-quality lamellae preparation

Advantages of METEOR 2.0

Reduced chance of contamination due to its integrated design increasing the imageable area of your lamellae

Fast sample screening and ROI identification to maximize cryo-FIB efficiency for high-throughput lamella milling

High resolution images for accurate ROI targeting to ensure you always capture the ROI in the lamella

Reliable ROI verification in final lamellae ensures optimal use of your valuable cryo-TEM time

Designed for adaptability, METEOR 2.0 evolves with your research needs in the rapidly advancing cryo-ET field

User-friendly and evolving automation software to minimize user interaction and free up your time

Reduce contamination and improve cryo-ET efficiency

Reduce the complexity of your cryo-correlative light and electron microscopy (cryo-CLEM) workflow using METEOR 2.0, an integrated cryo-fluorescent microscope retrofitted into a cryo-FIB/SEM*. Identify and verify the presence of the ROI in the safety of the high vacuum chamber without unnecessary transfer steps to a standalone cryo-FM. As a result, lower the chance of damage, contamination, and devitrification and increase the imageab

*METEOR is compatible with the following models: TFS Aquilos, TFS Hydra (Bio), TFS Scios, TFS Helios, TESCAN AMBER (2), TESCAN AMBER X (2), and ZEISS CrossBeam

Boost cryo-FIB productivity with fast ROI detection

With METEOR 2.0, you can screen your sample for potential milling sites in minutes—not hours. A large field of view, fast-switching filter wheel, and intelligent tiling, stitching, and autofocusing algorithms work together to give you a complete, high-resolution overview of your sample, faster than ever before. This means more cryo-FIB time for lamella milling—less on tedious ROI identification

Sample courtesy of Prof. Takayuki Kato, Institute for protein research, Osaka university

Maximize signal, minimize lamella damage

METEOR 2.0 combines the high photon collection capability of its high NA objectives with an optimized optical path to ensure maximum number of photons reach the camera. Additionally, the high quantum efficiency of the camera makes the most of these photons in image formation. As a result, even the weakest remaining fluorescence signal in the final lamellae can be detected by minimum excitation power, safeguarding the lamella from damage or devitrification.

Images courtesy of Oda Schioetz and Kristoph Kaiser, Max Planck Institute for Biochemistry, Martinsried, Germany

More lamellae, less effort

Meet ODEMIS—an advanced yet intuitive acquisition software designed to simplify imaging, accelerate workflows, and boost lamella production. With just one click, capture Z-stacks, overview images, and multi-channel fluorescence while integrated SEM/FM correlation and autofocus ensure seamless sample navigation.

ODEMIS integrates effortlessly with MAPS, AutoTEM, Essence, and ImageJ, making your workflow smoother than ever. As an open-source platform, it allows you to customize and automate processes with Python scripting. Plus, with free software updates, you always have access to the latest features to keep your research at the cutting edge.

Results

Imaging with METEOR

On-the-grid milling of plunge frozen yeast cells

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On-the-grid milling of plunge frozen yeast cells

Single field of view (left) and stitched overview map (right) of plunge frozen yeast cells. Sample courtesy of Prof. Takayuki Kato, Institute for protein research, Osaka university

Serial lift-out of waffle frozen C. elegans

Single field of view of waffle frozen C. elegans (left) and the lift-out sections on a receiver grid (right). Images courtesy of Oda Schioetz and Kristoph Kaiser, Max Planck Institute for Biochemistry, Martinsried, Germany

On-the-grid milling of plunge frozen mammalian cells

METEOR image of lamella overlaid with SEM image. Scalebar: 10 μm. Images courtesy of Dr. S. Berkamp (Forschungszentrum Jülich, Germany).

On-the-grid milling of plunge frozen Epithelial cells

Epithelial cells infected with HIV-1 virus-like particles (VLPs), post-mill. Scalebar: 10 μm. Images courtesy of Honkit Ng (Rockefeller University, USA). Samples courtesy of Francis Ashwanth (Florida State University, USA)

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Reach out to our team of specialists to find out how METEOR can help you improve your cryo-electron tomography workflow.

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Trusted by researchers in the field

“We believe this is the best solution given the axial resolution of conventional widefield microscopy and even confocal. Furthermore, with an integrated system, the fixed transformations between imaging modalities reduce the time cost of closely monitoring the fluorescence during the thinning process.”

Prof. Dr. Friedrich Förster Utrecht University

"Thanks to METEOR, it is wonderful to be finally able to check for signals at any time in the lamellae without any transfer steps and feel more sure about the presence of our target structures in the lamellae when we take them to the TEM for tomogram acquisition."

Anna Bieber, Cristina Capitanio and Oda Helene Schiøtz Max Planck Institute of Biochemistry in Martinsried