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METEOR

High-quality fluorescence imaging integrated into your cryo-FIB/SEM

Enhance your cryo-electron tomography (cryo-ET) process with a simplified workflow that bears superior output for your research

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In-situ fluorescent imaging made easy

Reduce risky transfer steps in your cryo-ET workflow and increase the effectiveness of region of interest (ROI) targeting to ensure high-quality lamellae preparation.

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Advantages of METEOR

More effective ROI targeting

High-quality optics to image challenging samples

Easier CLEM workflow with intuitive software

Reduced chance of damaged lamellae

Target your ROI effectively

Reduce the complexity of your cryo-correlative light and electron microscopy (cryo-CLEM) workflow using METEOR, an integrated cryo-fluorescent light microscope retrofitted into a cryo-FIB/SEM. Easily identify the ROI before milling lamellae by effortlessly switching between cryo-fluorescence light microscopy (cryo-FLM) and SEM, and lower the chance of damage, contamination, and devitrification.

Superb data quality

Benefit from high-quality optics to confidently mill at the correct area and accurately image challenging samples. Additionally, you can reinspect the sample with FLM directly after or during cryo-FIB milling to ensure high-quality lamellae for TEM imaging.

Customize according to your imaging needs

Customize the optical path of the METEOR by selecting the objective, camera, and emission filters according to your imaging needs, whether you work with plunge-frozen or high-pressure frozen samples, perform on-grid milling, or lift-out. You can easily change the configuration of METEOR as your research progresses to ensure long-lasting value.

Advanced user-friendly software

METEOR comes with ODEMIS, a user-friendly acquisition software that will ensure a smooth workflow to increase the throughput of lamellae production. You can acquire stitched overview images of the entire grid and navigate the sample with ease using the autofocus functionality. Stay up-to-date with free ODEMIS updates and add your own scripts to this open-source software.

METEOR is compatible with cryo-FIB/SEM systems of various vendors including Aquilos, Helios, and Crossbeam systems.

Results

Imaging with METEOR

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Microbiology

SEM and overlaid METEOR (FLM) images of a 1 μm thick lamella of yeast overexpressing eGFP-Ede1. Scalebar: 10 μm. Images courtesy of A. Bieber, C. Capitanio and O. Schioetz (MPI Biochemistry)

Microbiology

2-channel montage image of four 20-30 micron thick C. elegans with autofocus function. Scalebar: 25 μm. Image courtesy of Images courtesy of Samuel Zachej (TESCAN GROUP)

Cell biology

Pre-mill (left) and post-mill (right) METEOR (FLM) image of a 1.5 μm thick lamella of HeLa cells. Scalebar: 10 μm. Images courtesy of A. Bieber, C. Capitanio and O. Schioetz (MPI Biochemistry)

Cell biology

Autofluorescent vesicles of epithelial cells imaged by METEOR. Image courtesy of Honkit Ng and Keith Hamilton (Rockefeller University, USA)

Cell biology

In-situ correlative cryo-FIB milling on human RPE1 cells, mid-milling. Scalebar: 10 μm. Images courtesy of Dr. S. Berkamp (Forschungszentrum Jülich).

Pathology

Epithelial cells infected with HIV-1 virus-like particles (VLPs), post-mill. Scalebar: 10 μm. Images courtesy of Honkit Ng (Rockefeller University). Samples courtesy of Francis Ashwanth (Florida State University)

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Explore your options

Reach out to our team of specialists to find out how METEOR can help you improve your cryo-electron tomography workflow.

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Customers

Trusted by researchers in the field

“We believe this is the best solution given the axial resolution of conventional widefield microscopy and even confocal. Furthermore, with an integrated system, the fixed transformations between imaging modalities reduce the time cost of closely monitoring the fluorescence during the thinning process.”

Prof. Dr. Friedrich Förster Utrecht University

"Thanks to METEOR, it is wonderful to be finally able to check for signals at any time in the lamellae without any transfer steps and feel more sure about the presence of our target structures in the lamellae when we take them to the TEM for tomogram acquisition."

Anna Bieber, Cristina Capitanio and Oda Helene Schiøtz Max Planck Institute of Biochemistry in Martinsried