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Acquire more powerful insights to progress your research
Resolve optical properties at the nanoscale
Understand disease progression faster and more efficiently, help to diagnose patients, and develop new treatments with the power of high-throughput electron microscopy. Create 3D models of whole organs and advance the fundamental understanding of cancer.
Cancer is a heterogenous disease which can acquire multiple hallmarks throughout its multistep development in human tumors. The six main hallmarks are evading growth suppressors, resisting cell death, sustaining proliferative signaling, enabling replicative mortality, activating invasion and metastasis, and inducing angiogenesis (sprouting of new blood vessels). When looking at both cellular organization and interactions between (cancer) cells and the tumor microenvironment, all these hallmarks can be observed by using high-resolution imaging. 3D electron microscopy is a powerful diagnostic technique in cancer research and one of the most accurate ways to get an overview of the entire ultracellular structure on the nanoscale.
With the use of 3DSEM, it is possible to identify different tumorigenesis hallmarks, enabling distinction between healthy tissue and tumor cells. However, traditional SEMs are often not able to handle the workload required for imaging thousands of sections necessary to create a 3D model. With FAST-EM this bottleneck is eliminated: this ultrafast multibeam SEM allows fast and automated acquisition of multiple sections in a matter of hours. As a result, it opens the way for comparative studies, where 3DEM volumes from different tumors or biopsies are compared to discover features common during tumorigenesis.
Image large areas significantly faster and without the need for constant supervision. Acquire a large dataset to compare different samples or their parts, without compromising the image resolution.
Dr. Jacob Hoogenboom
-Faculty of Applied Sciences, TU Delft
