Opening new horizons in nanoscale biology
We turn high-throughput EM and cryo-ET into routine workflows, so you can move from heroic one-off experiments to everyday, high-impact nanoscale insight.
Our Dual Expertise in Life Sciences
Unlock powerful Cryo-ET insights
One integrated workflow, from fluorescence targeting to lamella milling, with no contamination, no fragmentation, and no wasted instrument time.
Sample handling, transfer, and storage under ultra-dry conditions (<50 ppm H₂O) minimise ice contamination. Integrated fluorescence microscopy means fewer transfer steps — and fewer chances for contamination to form. Together, that means cleaner lamellae and more high-quality tomograms.
Four specialised correlative workflows mean hitting your target every time. From automated correlative milling for abundant ROIs, to sub-200 nm Z-targeting for sparse and rare structures, plus FIB-view FM for fiducial-less HPF and waffle samples.
Sensitive fluorescence imaging detects even the weakest signal at low excitation power. So you can find your ROI, confirm it’s present in the final lamella, and do it all with no chance of devitrification.
Full support for on-grid, waffle milling, serial lift-out, and SOLIST means the workflow conforms to your sample and your science, not the other way around. Switching between preparation methods requires no new system, no new software — just a different protocol.
Three or more software platforms reduced to one: SEM, FIB, fluorescence imaging, and correlation all controlled from a single ODEMIS environment. Less time managing tools means more time generating data.
Unlock powerful nanoscale optical insights
Delmic’s FAST-EM technology redefines large-scale electron microscopy, by utilizing 64 parallel scanning beams to deliver high-throughput nanoimaging at unmatched speeds. Rapidly map entire thin sections without sacrificing resolution to accelerate your deep biological discovery.
At 4 nm pixel size, FAST-EM resolves sub-organelle detail across entire tissue sections — mitochondrial cristae, nuclear pores, endoplasmic reticulum — without choosing between resolution and coverage. The same image that shows organ anatomy at low magnification contains the ultrastructural data you need at high magnification.
64 parallel scanning beams acquire an entire thin section in a single pass, seamlessly stitched into one large-scale image. Multiple organs are visible simultaneously, so distribution effects, cross-organ pathology, and tissue-level context are never lost to field-of-view limitations.
Without substrate pockets to interrupt the scan path, the beam moves continuously across the section from start to finish. The result is a seamless, uninterrupted image with no gaps, no stitching artefacts at pocket boundaries, and no wasted acquisition time repositioning around obstacles.
The same 384 × 324 μm² zebrafish section that takes 4.5 hours on a conventional single-beam SEM takes 30 minutes on FAST-EM — 9 to 20 times faster depending on acquisition parameters. That speed difference changes what’s experimentally feasible: multiple time points, multiple samples, and reproducibility checks all become routine rather than exceptional.
Multi-section mounting lets you load and image multiple sections in sequence without manual intervention between runs. Combined with automated stage positioning and unsupervised acquisition, the instrument keeps working while your team focuses on the data — not the microscope.
Accelerate and deepen biological understanding
Delmic Life product line
High-quality fluorescence imaging integrated into your cryo-FIB/SEM.
A comprehensive cryo-ET targeting solution that reliably locates and confirms your ROI in the lamella across a wide range of sample types.
Minimize ice growth during cryo-ET lamellae preparation.
Eliminate ice contamination for a higher-throughput, more reliable cryo-ET workflow.
High throughput scanning electron microscope for biological samples.
Workflow results
From Virology to Pathology Discovery
A wild-type zebrafish embryo ~105 hours post fertilization (hpf)
Sample courtesy of B.H.P Duinkerken and B.N.G. Giepmans (University Medical Center Groningen, NL), A.J. Kievits, E.C. Carroll, and J. Hoogenboom (Technical University of Delft, NL).
AI segmented mitochondria in a rat kidney section
Sample courtesy of :
N. Liv, University Medical Center Utrecht, NL
Drosophila egg chamber with green autofluorescence
Sample courtesy of: Dr. Sven Klumpe, Max Planck Institute for Biochemistry, Martinsried
Synaptic vesicle distribution in primary rat neurons
Sample courtesy of: Thao Do, Arsen Petrovic and Jenny Prisca, Institute of Neuropathology, UMC Gottingen, Germany
Yeast cells expressing TCb3 tagged with GFP
Sample courtesy of:Thao Do, Arsen Petrovic and Jenny Prisca, Institute of Neuropathology, UMC Gottingen, Germany
Clean lamella achieved by using the Clean Station
Sample courtesy of Jean Daraspe, EM Facility, University of Lausanne, Switzerland
Waffle frozen C.elegans
Sample courtesy of Oda Schiøtz and Christoph Kaiser, Max Planck Institute for Biochemistry, Martinsried
Delmic is present in 5 continents, supporting over 200 publications and counting.
Testimonials
See what world-class institutions have achieved with Delmic’s Life science technologies
“The nicest part is that their [Delmic] products live up to their specifications and are offered at a competitive cost.”
Reza Paraan, Postdoctoral Researcher
New York Structural Biology Center (NYSBC).
“We believe this is the best solution given the axial resolution of conventional widefield microscopy and even confocal. Furthermore, with an integrated system, the fixed transformations between imaging modalities reduce the time cost of closely monitoring the fluorescence during the thinning process.”
Prof. Dr. Friedrich Förster
The in situ Structural Biology Lab at Utrecht University
“With FAST-EM, we can go to larger volumes. For instance, it could be used for a full model animal brain to map out all the neurons' connections.”
Dr. Jacob Hoogenboom
The Faculty of Applied Sciences at TU Delft.
“Without the FAST-EM, we can not image 1 by 1-millimeter sample over the weekend, with the FAST-EM we will be able to do that over a couple of hours.”
Dr. Ben Giepmans
University Medical Center Groningen (UMCG).
“I would absolutely recommend the CERES Clean Station to other researchers. While working in a glove box requires some adjustment, it is far better than spending days on Lift-Out projects only to end up with contaminated lamellae. The Clean Station is a compact, energy-efficient solution that solves a major problem in our workflow.”
Jean Daraspe
Université de Lausanne – Laboratory Scientific Expert
