High-quality fluorescence imaging and accurate targeting integrated with your cryo-FIB/SEM

METEOR 2.0

Product Overview

Reduce ice contamination
Fast region-of-interest detection
Reliable ROI verification in final lamellae
User-friendly, evolving software
A future-proof system

Details:

The integrated design reduces back-and-forth transfers between instruments, lowering contamination risk and increasing the imageable area of your lamellae.

Details:

A large field of view, fast-switching filter wheel, and intelligent tiling, stitching, and autofocusing algorithms enable rapid sample screening and ROI identification—maximizing cryo-FIB efficiency for high-throughput lamellae milling.

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By combining high-NA objectives, an optimized optical path, and a high-quantum-efficiency camera, METEOR 2.0 maximizes photon collection to detect the faintest fluorescence at minimal excitation power—safeguarding the lamellae from damage and devitrification.

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Continually evolving, easy-to-use software minimizes manual interaction and frees up your time.

Details:

Designed for adaptability, METEOR 2.0 evolves with your research needs in the rapidly advancing field of cryo-ET.

Software Overview

3+ software tools in one interface
Full-grid overview maps with autofocus
Automated workflows
Shaped by user feedback
Evolving and shaped by customer feedback

Details:

SEM, FIB, fluorescence imaging, and correlation all controlled from a single ODEMIS environment.

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Full-grid overviews are captured and stitched automatically, with autofocus that compensates for grid imperfections.

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FM Z-stack acquisition and lamella milling run automatically, freeing the operator to step away from the instrument while the system keeps working.

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Guided SEM/FM and FIB/FM alignment is accurate and straightforward, with no manual file transfer between tools — correlation that used to take hours now takes minutes.

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The system automatically identifies and targets the correct lamellae position after each milling step, eliminating the need for manual re-correlation. Accuracy is maintained throughout the entire workflow, regardless of how many iterations the sample goes through.

Results Imagery

Imaging with Delmic’s
METEOR technology

Overall Advantages

Cleaner lamellae

Fewer transfer steps mean less ice contamination.

.01

Targeting in any sample type

Accurate workflows for cell-on-grid, waffle, and high-pressure frozen samples.

.02

Maximum signal, minimal damage

Sensitive, industry-leading optics reveal your ROI even at low excitation power.

.03

More lamellae, less effort

Automated correlative milling in a single software environment.

.04

Future-proof and open-source

Modular design and regularly updated software keep pace with the fast-moving cryo-ET field.

.05

Overall
Advantages

Yeast cells expressing Abp140-GFP

Sample courtesy of:

Oda Schiøtz and Christoph Kaiser, Max Planck Institute for Biochemistry, Martinsried

Waffle frozen C.Elegans containing green autofluorescence and exterior of pharyngeal muscle tagged with mKate

Sample courtesy of:

None

Overview map of waffle frozen C.Elegans

Sample courtesy of:

Oda Schiøtz and Christoph Kaiser, Max Planck Institute for Biochemistry, Martinsried

Drosophila egg chamber with green autofluorescence

Sample courtesy of:

Dr. Sven Klumpe, Max Planck Institute for Biochemistry, Martinsried

Primary rat neurons

Sample courtesy of:

Thao Do, Arsen Petrovic and Jenny Prisca, Institute of Neuropathology, UMC Gottingen, Germany

Synaptic vesicle distribution in primary rat neuron

Sample courtesy of:

J.P. Baudoin, AP-HM (Marseille, FR)

Lamella of yeast cells expressing Abp140-GFP

Sample courtesy of:

Prof. Takayuki Kato, Institute for protein research, Osaka university

Lamella of HeLa cell with nucleus (blue) and mitochondria (red) labelling and green autofluorescence from lysosomes

Sample courtesy of:

JEOL

Serial-lift-out lamellae of C.Elegans containing green autofluorescence and exterior of pharyngeal muscle tagged with mKate

Sample courtesy of:

Oda Schiøtz and Christoph Kaiser, Max Planck Institute for Biochemistry, Martinsried

Drosophila egg chamber with green autofluorescence

Sample courtesy of:

Dr. Sven Klumpe, Max Planck Institute for Biochemistry, Martinsried

Overview map of yeast cells expressing TCb3 tagged with GFP

Sample courtesy of:

Thao Do, Arsen Petrovic and Jenny Prisca, Institute of Neuropathology, UMC Gottingen, Germany

Yeast cells expressing TCb3 tagged with GFP

Sample courtesy of:

Thao Do, Arsen Petrovic and Jenny Prisca, Institute of Neuropathology, UMC Gottingen, Germany

Current vacancies

At the moment, we don’t have any open positions, but please keep an eye out for new opportunities as we expect new roles to open soon.

SPARC Spectral 3.0

By Delmic

High-performance and multimodal cathodoluminescence detector for SEM.

Gain fast and reliable access to nanoscale optical insights using, uncovering information that other analytics techniques fail to resolve.



→ Highly efficient optical design ensures maximal sensitivity and throughput

→ Large field-of-view to map large regions of interest

→ Automated and guided workflows ensures reliable data collection across users and sesions.

Compatible with: all major SEMs brands

METEOR 2.0

By Delmic

Cryo fluorescence microscope — integrated into your cryo-FIB/SEM system.

Eliminate sample transfers and guide lamella milling with precise fluorescence targeting, right inside your cryo-FIB/SEM system, thanks to its integrated fluorescence light microscope.

→ Integrated design reduces contamination risk and maximises imageable lamella area

→ Large field of view, fast-switching filter wheel, and smart tiling, stitching, and autofocus for rapid ROI identification

→ High-NA optics and a high-quantum-efficiency camera detect the faintest fluorescence at minimal excitation power, protecting lamellae from damage and devitrification

→ Easy-to-use, continually evolving software that minimises manual interaction and frees up your time

→ A future-proof system that adapts and evolves with your research in the fast-moving field of cryo-ET